Building Place-Based Initiatives for Boys and Men of Color and Vulnerable Populations: A Community Planning Guide

This guide provides information about how communities can implement the next phase of achieving priority outcomes for boys and men of color. It focuses on two critical areas of work: 1) how to conduct a policy review and formulate recommendations for action and 2) how to develop an action plan. The following sections contain specific guidelines for taking these next steps. In addition, the appendices include a template for organizing the policy review and suggested components of the action plan

Advances in oral transmucosal drug delivery

Original article can be found at : http://sciencedirect.com/ Copyright ElsevierThe successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities for buccal/sublingual drug delivery. Particular attention is given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides. The review will also discuss the physiology and local environment of the oral cavity in vivo and how this relates to the performance of transmucosal delivery systems.Peer reviewe

Long-Term Dynamics and the Orbital Inclinations of the Classical Kuiper Belt Objects

We numerically integrated the orbits of 1458 particles in the region of the classical Kuiper Belt (41 AU < a < 47 AU) to explore the role of dynamical instabilities in sculpting the inclination distribution of the classical Kuiper Belt Objects (KBOs). We find that the selective removal of low-inclination objects by overlapping secular resonances (nu_17 and nu_18) acts to raise the mean inclination of the surviving population of particles over 4 billion years of interactions with Jupiter, Saturn, Uranus and Neptune, though these long-term dynamical effects do not themselves appear to explain the discovery of KBOs with inclinations near 30 degrees. Our integrations also imply that after 3 billion years of interaction with the massive planets, high inclination KBOs more efficiently supply Neptune-encountering objects, the likely progenitors of short-period comets, Centaurs, and scattered KBOs. The secular resonances at low inclinations may indirectly cause this effect by weeding out objects unprotected by mean motion resonances during the first 3 billion years.Comment: 23 pages, including 10 figures. Accepted for publication in A

The Structural Estimation of Principal-Agent Models by Least Squares: Evidence from Land Tenancy in Madagascar

We develop a method to structurally estimate principal-agent models by ordinary least squares (OLS). We set up a general principal-agent model which explicitly incorporates the wealth levels of each party and the opportunity cost to the agent of entering the contract. This yields an optimal contract that is linearized by way of an Nth order Taylor approximation. This in turn imposes N(3N-1)/2 restrictions on the parameters and yields an empirical test of the canonical principal-agent model. In the application, we consider the case where N = 2 and apply our method to a sample of land tenancy contracts in rural Madagascar. Empirical tests lead to consistent failure to reject the hypotheses derived from our structural model, which lends support to our structural method as well as to the canonical principal-agent model.Principal-Agent Models, Contract Theory, Structural Estimations, Risk and Uncertainty, C12, C13, D86, O12, Q12,

A Search for Resonant Structures in the Zodiacal Cloud with COBE DIRBE: The Mars Wake and Jupiter's Trojan Clouds

We searched the COBE DIRBE Sky and Zodi Atlas for a wake of dust trailing Mars and for Trojan dust near Jupiter's L5 Lagrange point. We compare the DIRBE images to a model Mars wake based on the empirical model of the Earth's wake as seen by the DIRBE and place a 3-sigma upper limit on the fractional overdensity of particles in the Mars wake of 18% of the fractional overdensity trailing the Earth. We place a 3-sigma upper limit on the effective emitting area of large (10-100 micron diameter) particles trapped at Jupiter's L5 Lagrange point of 6 x 10^17 cm^2, assuming that these large dust grains are distributed in space like the Trojan asteroids. We would have detected the Mars wake if the surface area of dust in the wake scaled simply as the mass of the planet times the Poynting-Robertson time scale.Comment: Sixteen pages, and figures 1, 2, 3a, 3b, 4, 5, 6, and 7. Accepted for publication in Icaru

Diffusion through the ex vivo vitreal body - bovine, porcine, and ovine models are poor surrogates for the human vitreous

© 2018 The Authors. Published by Elsevier B.V.The human vitreous humour is a complex gel structure whose composition and physical properties can vary considerably from person to person and also change with age. To date, the viscoelastic properties of the human vitreous gel has not been thoroughly investigated and despite many years of intensive research, an ideal vitreous substitute remains a challenge. Understanding the physical structure and properties of the vitreous is of fundamental and therapeutic interest, providing a clear insight into diffusion and transport of administered ophthalmic drug molecules into the vitreous. A number of mammalian surrogates, mainly bovine, porcine and ovine vitreous humours have been greatly used in the literature as a means of studying ophthalmic drug transport and diffusion. In this study, the mechanical, physical and rheological properties of ovine, porcine, and bovine surrogates were investigated and compared to human vitreous. In addition, a bespoke Franz cell construct was used to compare the diffusion of a model drug (i.e. fluorescein) through vitreous samples. Despite the similarity in rheological properties between bovine, porcine and human vitreous samples (p > 0.05), diffusion of fluorescein through the different vitreous samples revealed great differences in values of steady-state flux and diffusion coefficient. In addition, a first-generation vitreous mimic, composed of 4.5 mg/mL hyaluronic acid with complex viscosity of 0.3 ± 0.01 Pa has been evaluated and was demonstrated to be a better mimic of the human vitreous than the mammalian samples investigated.Peer reviewedFinal Published versio

One-Dimensional Multi-Frame Blind Deconvolution Using Astronomical Data for Spatially Separable Objects

Blind deconvolution is used to complete missions to detect adversary assets in space and to defend the nation\u27s assets. A new algorithm was developed to perform blind deconvolution for objects that are spatially separable using multiple frames of data. This new one-dimensional approach uses the expectation-maximization algorithm to blindly deconvolve spatially separable objects. This object separation reduces the size of the object matrix from an NxN matrix to two singular vectors of length N. With limited knowledge of the object and point spread function the one-dimensional algorithm successfully deconvolved the objects in both simulated and laboratory data